Electronic data capture (EDC) for clinical trials often follows a paper processing model. Following such a model is straightforward and can ease adoption of what may be new technology for an organisation. This approach, however, misses opportunities to leverage the technology to achieve further benefits. Karina Loyo, eClinical Trials Specialist, and Alicia A. Browner, Chief Technology Officer, at Prelude Dynamics, explain how to take full advantage of the EDC by providing practical information on shifting operational practices to the new trial management EDC system paradigm.